John Daniel Tooz Matuszak was an American football defensive lineman in the National Football League and also an actor. Matuszak was born in Oak Creek, Wisconsin. He attended the University of Tampa and played for their football team. Matuszak also played for the Houston Oilers of the NFL and joined the Houston Texans of the World Football League, but never played for them. His first major role as an actor was in the 1979 movie "North Dallas Forty" as a football player. He also appeared in the movies "Caveman", "The Ice Pirates", and "One Crazy Summer" but is known for his role in "The Goonies". He also had guest appearances on popular TV shows "Perfect Strangers", "M*A*S*H", "The Dukes of Hazzard", "Hunter", "Silver Spoons", "The A-Team", "1st & Ten", "Miami Vice" and "Cheers". He died on June 17, 1989 aged 38 due to a heart failure.
Because steroids are lipophilic, they diffuse easily through the cell membranes, and therefore have a very large distribution volume. In their target tissues, steroids are concentrated by an uptake mechanism which relies on their binding to intracellular proteins (or " receptors ", see below). High concentration of steroids are also found in adipose tissue, although this is not a target for hormone action. In the human male, adipose tissue contains aromatase activity, and seems to be the main source of androgen-derived estrogens found in the circulation. But most of the peripheral metabolism occurs in the liver and to some extent in the kidneys, which are the major sites of hormone inactivation and elimination, or catabolism (see below).
Acne is often present. Acne conglobata is a particularly severe form of acne that can develop during steroid abuse or even after the drug has been discontinued. Infections are a common side effect of steroid abuse because of needle sharing and unsanitary techniques used when injecting the drugs into the skin. These are similar risks to IV drug abusers with increased potential to acquire blood-borne infections such as hepatitis and HIV/AIDS . Skin abscesses may occur at injection sites and may spread to other organs of the body. Endocarditis or an infection of the heart valves is not uncommon.