The partition coefficient of the ester in question is important because is effects how long the drug itself stays in the system. If the testosterone transfers too quickly from the oil to the blood, the result is a sudden spike in testosterone which then rapidly drops once the dose has been used up. In the example of free testosterone injected into the muscle from a water suspension (as in Aquiviron, mentioned above), the testosterone is essentially immediately available to the bloodstream due to its low partition coefficient, and thus there is an immediate spike of testosterone which is used up quickly in the body.
There are no available data on the presence of fluticasone propionate in human milk, the effects on the breastfed child, or the effects on milk production. Other corticosteroids have been detected in human milk. However, fluticasone propionate concentrations in plasma after inhaled therapeutic doses are low and therefore concentrations in human breast milk are likely to be correspondingly low [see Clinical Pharmacology ()] . The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Flovent HFA and any potential adverse effects on the breastfed child from Flovent HFA or from the underlying maternal condition.
Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use CLOBEX® Shampoo (clobetasol propionate shampoo) for a condition for which it was not prescribed. Do not give CLOBEX® Shampoo (clobetasol propionate shampoo) to other people, even if they have the same symptoms you have. It may harm them. This leaflet summarizes the most important information about CLOBEX® Shampoo (clobetasol propionate shampoo) . If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about CLOBEX® Shampoo (clobetasol propionate shampoo) that is written for health professionals.