In the UK, Peter Bradshaw of The Guardian awarded the film a maximum five stars, calling it "a gripping psychological thriller about big pharma and mental health that cruelly leaves you craving one last fix". He praised the lead performance from Rooney Mara as "compelling" who "lays down the law with her presence. She demonstrates a potent Hitchcockian combination: an ability to be scared and scary at the same time, and Soderbergh's film manages to introduce its effects in some insidious, almost intravenous way".  The . Club ' s Scott Tobias called Mara "superb as the glue that binds this fractured psychological puzzle," and commended Soderbergh's sophisticated direction: " Side Effects screws around in its own thriller architecture, toying with feints of structure and clever bits of misdirection, and otherwise playing the audience like a fiddle. At this point in his career, Soderbergh pulls it off with the unpracticed ease of a maestro."  Robbie Collin of The Daily Telegraph awarded Side Effects a maximum five stars and also acknowledged its debt to earlier psychological thrillers. He wrote: "There's a lot of Alfred Hitchcock in what follows, but even more Henri-Georges Clouzot , with whose classic spine-tingler Les Diaboliques (1954) Soderbergh's film shares a poisonous tang".  Peter Travers of Rolling Stone praised the film's performances, the script and direction, writing "Soderbergh delivers ticking-bomb suspense laced with psychological acuity about a world where mood-altering meds are as disturbingly prevalent as social media". 
I am a two-time survior of the devasting bacterial infection known as C-Diff. Since I am an otherwise completely healthy female (was 35 and 44 when I contracted), it was unexpected that the disease would nearly kill me – twice. I have taken liquid vancomycin for nearly nine months now, but it has not cured me. I had the good fortune of learning from my infectious disease doctor and obtaining an opinion from an expert at Johns Hopkins Hospital about my case, and both concurred that I should consider opting for a fecal transplant as vancomycin hasn’t cured me. Although the procedure is usually done at the hospital and is 90-95% effective (so I am told), my husband and I are doing the home-style version. A fecal transplant is done by taking the stole of a healthy, close family member, mixing it with saline solution in a blender, putting it through a seive, and “inplanting” the donor’s good bacteria via an enema bottle into your intestines via your rectum. Although it was quite disgusting the first day, it gets easier. I noticed a dramatic improvement within 12 hours. Anyone having gone through a severe case of C-Diff knows that the fecal transplant procedure is not nearly as tramatic and painful as living with this infection. Quite frankly, the fecal transplant may save my life.