Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS ).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular Disorders: venous thromboembolism
Miscellaneous: Inflammation and pain at the site of intramuscular injection.
Androgens stimulate protein synthesis in muscle, and they usually do not affect the overall synthesis in the organism. Androgens stimulate the production of red blood cells by synthesis and secretion stimulation of erythropoietin, direct stimulation of hematopoiesis in bone, marrow stimulation and inclusion of iron ions in the red blood cells. Although the use of androgens causes a significant increase in hematocrit and hemoglobin levels. At the same time in healthy men, when testosterone enanthate is applied in amounts of 200 mg per week, during 16 weeks cycle, the significant increase in the number of red blood cells and the increase in the hematocrit and hemoglobin were observed.
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