In 1971, Knoll showed that selegiline selectively inhibits the B-isoform of monoamine oxidase ( MAO-B ) and proposed that it is unlikely to cause the infamous "cheese effect" ( hypertensive crisis resulting from consuming foods containing tyramine ) that occurs with non-selective MAO inhibitors. A few years later, two Parkinson's disease researchers based in Vienna, Peter Riederer and Walther Birkmayer, realized that selegiline could be useful in Parkinson's disease. One of their colleagues, Prof. Moussa . Youdim , visited Knoll in Budapest and took selegiline from him to Vienna. In 1975, Birkmayer's group published the first paper on the effect of selegiline in Parkinson's disease.  
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